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Drivers for the DJM-900NXS2 are available on the support website.
The DJM-900NXS2 will work with most major software as an audio device, however it will not work with Serato DJ at this time (as it does not "unlock" the software), nor will it work with Traktor for timecode input (as it is not "certified").
It can be used with djay, Traktor or Virtual DJ for output.