@Andrew > We're going to need a whole heap more information in order to even get started on answering this one....
1) What is your computer spec (CPU / RAM / OS)?
2) What is the make / model of the graphics card / chipset & driver version (if on PC)?
3) Are you running any plugins (eg. DVS or video)?
4) What is the Waveform Drawing Rate set to in the preferences?
5) What is the filetype you're loading? Does it happen with all filetypes?
6) What is the source location of those files? Where is your database located (internal / external)?