What type of audio files are you using? WAV, AIFF, Mp3?
Where is your source? Beatport, Pirate Download sites, etc...?
All of my music comes from Beatport, in AIFF format. In my experience, the first beat is lined up correctly about 50% of the time. Of those 50% of tracks that are correct from the start, about 50% of those require adjustment to the grid spacing to be aligned at the end. Grid adjustment must be done manually and checked against the metronome.
About 10-15% of the time when I load a new track, the first beat will be out of line and the red beat will be on the wrong beat. This must be fixed manually.