
@Josh > The CDJ-350's will connect directly via USB to your computer running Serato and use HID mode. you will program 1 CDJ to control 1 deck in Serato, and the other CDJ to control the other deck. You will then need to connect your RCA out of the CDJ's and into the proper channels on your DJM. This will eliminate the Serato box. The DJM-350 does not have a USB output on it, so when you run the RCA's into the back of the DJM-350, you will use the mixer as an actual hardware controller and it will not effect the software. Then you just need to connect some cables to your master output on the DJM to some active speakers or an amp and you should be good to go.
Reply here if you have any issues during the setup stages, and be sure to check the forums first for similar posts and solutions. :)