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Your computer, while powerful, is a gaming computer - and as such, the system will typically prioritize the graphics over continuous audio performance. The DDJ-400 itself and the drivers are fine. One of the things you could try is updating the graphics drivers from the NVIDIA site (not MSI, and not Windows), and also ensure that you have disabled any background applications - I know MSI ships with apps that are supposed to give a "performance boost" to the system, but they cause problems.
The other thing to check is that you have disabled the Intel turbo-boost function, either in the BIOS / UEFI, or by adjusting the Windows power management profile to throttle the CPU to a maximum of 99%.