Sure - you could use an application such as Traktor or VDJ and map the controls such that one of the buttons (eject, perhaps?) is the MIDI signal for "Toggle Focus" and thus the play button would work for each deck. The only problem you may have, depending on your setup configuration, is how the audio is output from the computer. If you're using a DJM with a built-in audio interface, then you would send each channel from the software to a different channel on the mixer and that's no problem.
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