Set as output for what, your DJ software or the macOS audio output?
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I have this problem as well
PLugged Speakers into DDJ-SB3 and set output as SB3 on Mac still no sound
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MacOS Audio output
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Do you have the channel 1 trim and level up, as well as the master?
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heres my settings 
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Your Master volume is really low and the channel 1 filter is all the way up.
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Ive rectified these two settings but still no speaker output
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