Hey Kevin,
Two things to check...
1) If the SX2 is set as the Windows default output audio device, this can happen. Open the Windows sound settings and change it to your internal audio device.
2) Should that not be it, with Serato closed, try opening the \Music\_Serato_ folder and rename the MIDI folder to MIDI-OLD. Launch Serato and see if the problem persists.
Let us know if that works.
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